Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Cambridge dictionary
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Cambridge International Dictionary of English was published in 1995 and then published under the name Cambridge Advanced Learner's Dictionary, by the Cambridge University Press. It has references to over 170,000 words, phrases and examples explained.
Cambridge dictionary meaning & definition 1 of Cambridge dictionary.
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