Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Wrecker
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One who causes a wreck, as by false lights, and the like.
Wrecker meaning & definition 1 of Wrecker.
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A really strong person who could beat the shit out of you.
Wrecker meaning & definition 2 of Wrecker.
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A large party usually with alcoholic beverages.
Derived from House Wrecker.Wrecker meaning & definition 3 of Wrecker.
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arse hole, crap pipe, clay lane, tradesmans entrance, rusty bullet hole, sheriffs badge, teatowel holder, ringhole, ring piece, turd pipe, brown eye...etc
Wrecker meaning & definition 4 of Wrecker.
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When Your sweet adorable boyfriend has a huge thick dick and wrecks your pussy like a wrecking ball
Wrecker meaning & definition 5 of Wrecker.
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A person or thing that wrecks something.
Wrecker meaning & definition 6 of Wrecker.
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