Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Viz-cacha
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A large burrowing South American rodent (Lagostomus
trichodactylus) allied to the chinchillas, but much larger. Its fur is
soft and rather long, mottled gray above, white or yellowish white
beneath. There is a white band across the muzzle, and a dark band on
each cheek. It inhabits grassy plains, and is noted for its extensive
burrows and for heaping up miscellaneous articles at the mouth of its
burrows. Called also biscacha, bizcacha, vischacha, vishatscha.
Viz-cacha meaning & definition 1 of Viz-cacha.
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