Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Ability
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The quality or state of being able; power to perform, whetherphysical, moral, intellectual, conventional, or legal; capacity;skill or competence in doing; sufficiency of strength, skill,resources, etc.; -- in the plural, faculty, talent.Then the disciples, every man according to his ability, determined tosend relief unto the brethren. Acts xi. 29.Natural abilities are like natural plants, that need pruning bystudy. Bacon.The public men of England, with much of a peculiar kind of ability.Macaulay.
Ability meaning & definition 1 of Ability.
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The natural equipment to accomplish some small part of the meaner ambitions distinguishing able men from dead ones. In the last analysis ability is commonly found to consist mainly in a high degree of solemnity. Perhaps, however, this impressive quality is rightly appraised; it is no easy task to be solemn.
Ability meaning & definition 2 of Ability.
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Forming nouns of quality corresponding to adjectives ending in -able (such as suitability corresponding to suitable).
Ability meaning & definition 3 of Ability.