Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Oillet
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A small opening or loophole, sometimes circular, used in
mediaeval fortifications.
Oillet meaning & definition 1 of Oillet.
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In the times of [castle] warfare, these were windows that went through thick walls of the front of [the castle] where the window was wider on the inside than on the outside. A benefit to such windows is it was easy to fire an [arrow] out, but archers on the outside would have trouble firing back at you.
A word that rhymes with toilet.Oillet meaning & definition 2 of Oillet.
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An aperture or loophole for observation, especially in a wall; = eyelet. Now (Architecture): a round opening at the end of an arrow-slit (historical).
Oillet meaning & definition 3 of Oillet.
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