Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Monotone
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The utterance of successive syllables, words, or
sentences, on one unvaried key or line of pitch.
Monotone meaning & definition 1 of Monotone.
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A continuing sound, especially of a persons voice, that is unchanging in pitch and without intonation.
Monotone meaning & definition 2 of Monotone.
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when a person is so [fucking gay] that they cant even raise their voice. they only have one tone like emma, [elliot], and [mr johnson]. they cant use exclamation points or queston marks.
Monotone meaning & definition 3 of Monotone.
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