Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Exclamation
-
A loud calling or crying out; outcry; loud or emphatic
utterance; vehement vociferation; clamor; that which is cried out, as
an expression of feeling; sudden expression of sound or words
indicative of emotion, as in surprise, pain, grief, joy, anger, etc.
Exclamation meaning & definition 1 of Exclamation.
-
The act of exclaiming; outcry; loud [complaint] or [protest].
Exclamation meaning & definition 2 of Exclamation.
-
Single words or short phrases yelled during the act of sexual intercourse. Often used at times of extreme pain, pleasure, or while climaxing.
Exclamation meaning & definition 3 of Exclamation.
Similar Words