Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Gender-fluid
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A gender-fluid person doesnt have a single gender. Sometimes they wont even identify with a gender. Somedays Ill feel more feminine so Ill dress and identify myself with a female and other days I will feel more masculine, Ill dress and identify myself with a male. All the other days I feel like both or neither.
Gender-fluid meaning & definition 1 of Gender-fluid.
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