Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Cockies
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A line of men lying down next to one another with thier erections in the air, resembling the Rocky Mountains whilst a woman goes down the line and blows each one, henceforth tapping the Cockies, but instead of beer, there is sperm...everywhere.
Cockies meaning & definition 1 of Cockies.
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