Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Polar opposites
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The complete opposite to one another.
such as the polar points (North and South) are directly opposite each other on the earths surface and do not meet or overlap at all.
in chemistry, there is polarity, which has to do with atomic structure. Water and oil do not mix because water is polar and oil is non-polar.
Polar opposites meaning & definition 1 of Polar opposites.
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