Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
June bug
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Little brown beetles famous for thier incesant bumping into porch lights and houses on a late spring to summer evening. Often tries to sneak into houses, either by flying right in when the door is open, or by hitching a ride on somebodys clothes like a little ninja. Harmless to humans and cannot bite. Despite thier name, they can come out as early as May.
June bug meaning & definition 1 of June bug.
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