Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Deer in the headlights
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Deer in the Headlights is a great game when 2 people dress up in a 1 deer costume and walk in front of cars unexpectedly and hope to not get it.
This is best to do in a neighborhood or school zone.
Best to do at night.
Deer in the headlights meaning & definition 1 of Deer in the headlights.
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when a man is receiving oral sex from his partner and chooses at a random time to stick his fingers in his partners ears resulting in a surprised partner with bulging eyes and two thumbs up look like antlers.
Deer in the headlights meaning & definition 2 of Deer in the headlights.
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