Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
P's and q's
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From an old printers axiom. Back in the early days of printing presses, each line of text had to be set up one letter at a time. Since the letters in the press were reversed (so theyd print forward), the printmaker (or typographer) needed to be careful not to confuse one letter for the other.
Reminding someone to watch his ps and qs means to pay attention to the details.
P's and q's meaning & definition 1 of P's and q's.
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