Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Rant
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--1.
-a novel by Chuck Palahniuk (author of Fight Club)
--2.
-the titular character of the novel of the same name. His real name is Buster L. Casey but his nickname Rant came from a childhood prank involving animal organs which resulted in numerous people getting sick. As each person threw up, they made a sound that resembled the word rant, which became a local synonym for vomit and Busters nickname.
He starts a tooth fairy scheme involving gold pieces which changes the economy of his town, deliberately gets bitten by spiders, snakes, coyotes, etc. until he gets rabies, spreads it other ppl and then moves to the big city where he participates in a demolition derby known as Party Crashing.
--3.
-to throw up or vomit. originates from the book Rant.
Rant meaning & definition 1 of Rant.