Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Hob
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A threaded and fluted hardened steel cutter, resembling a tap,used in a lathe for forming the teeth of screw chasers, worm wheels,etc.
Hob meaning & definition 1 of Hob.
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noun: a creepy old man (elderly one) who enjoys hitting on younger, foxy ladies. short for horny old bastard.
Hob meaning & definition 2 of Hob.
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A British English term for the cooker rings on a gas/electric stove top. It is hot
Hob meaning & definition 3 of Hob.
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