Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Thunder buddy
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A friend or object that you keep close when you are nervous about a certain situation that frightens, or anytime there is a literal thunder storm.
Thunder buddy meaning & definition 1 of Thunder buddy.
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noun: someone who is always there for you throughout a thunder storm to keep you safe from danger.
referenced in the hit movie Ted
Thunder buddy meaning & definition 2 of Thunder buddy.
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When your friend unknowingly traps you against a wall or hard surface while pressing their ass against your ass and farting. The essence of the succulent smell transfers to the cloths of the thunder buddy
Thunder buddy meaning & definition 3 of Thunder buddy.
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