Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Swamp ass
-
A common condition in which the ass crack and crotch becomes overly moist, sweaty, and stinky from one or all of the following:
sweating on a hot day
not bathing enough
long day of work, sports, play
incomplete wipe due to rush or lazinessThe crack will often feel squishy, wet, unpleasant, and itchy. It is recommended to take a bath with soap to sanitize the condition.
Swamp ass meaning & definition 1 of Swamp ass.
-
when you get hot and your ass sweats. it makes for a bad time
Swamp ass meaning & definition 2 of Swamp ass.
-
Some one who does not wipe there ass or has not tooken a shower recently and stinks like shit
Swamp ass meaning & definition 3 of Swamp ass.
-
An unfortunate condition in which the taint (the often hair-bespeckled, flrshy space between balls and ass) is wallowing in the depths of a vile, festering, putrid poo swamp. A generally uncomfortable, unwipable ass. The only cure is gold bond.
Swamp ass meaning & definition 4 of Swamp ass.
-
A build up of sweat and schmancter usually forming on the under carriage in the crease between the berry bag and the inner thigh. After aging, swamp ass can put out a distinct and distasteful odor. Swamp ass is caused by extended periods of physical activity. Obesity can contribute to the severity.
Swamp ass meaning & definition 5 of Swamp ass.
-
A condition caused by excessive moisture build up on ones ass, creating a very uncomfortable and disgusting situation in anal region.
Swamp ass meaning & definition 6 of Swamp ass.
-
The origin of this problem is the ass crack. Once sweaty it begins to get itchy, like you did not wipe well enough. After it gets unbearable you begin to scratch like crazy, and shortly thereafter your whole ass feels like one big cactus has spanked you for hours.
Swamp ass meaning & definition 7 of Swamp ass.
-
@mark-zuckerberg no such word as tooken
Swamp ass meaning & definition 8 of Swamp ass.