Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Negative
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Another way of saying no.
Negative meaning & definition 1 of Negative.
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The direct opposite of the words [positive] and [affirmative].
Negative meaning & definition 2 of Negative.
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A Finnish love rock band. Their frontman is called Jonne Aaron.
Negative meaning & definition 3 of Negative.
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When u say [no] in a walk talkie.
Negative meaning & definition 4 of Negative.
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The best movie ever, directed by Zach Lorkiewicz and Clement Wink
Released Oct. 28
Go see itNegative meaning & definition 5 of Negative.
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Self-indulgent. Whatever one might do without thinking twice about it, even if it causes harm to others.
Negative meaning & definition 6 of Negative.
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A person who tans excessively and bleaches their hair. Similar to a persons image in a photographic negative.
Negative meaning & definition 7 of Negative.
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