Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Impacted
-
So stuffed with dicks, there is no space for anything else.
Impacted meaning & definition 1 of Impacted.
-
Pressed firmly together.
Impacted meaning & definition 2 of Impacted.
-
An impacted tooth cannot grow in the right way, usually because it is growing against another tooth below the gum .
Impacted meaning & definition 3 of Impacted.
Similar Words