Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Yahoo!
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Email service/search engine/news site (sort of) that does fairly good with the e-mail and search engine parts but is either passing some stupid story about a worthless celebrity either wearing something they consider weird off as news. When they do talk about real news, the comments section is always filled with republican nutjobs who have no idea what they're talking about.
Yahoo! meaning & definition 1 of Yahoo!.
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Declaration of joy.
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Seach engine/life engine.
Yahoo! meaning & definition 2 of Yahoo!.
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Yahoo! is one of the Internets leading search engines. It is also the largest Web portal, providing links to thousands of other websites. These links include sites from the Yahoo! Directory as well as news stories that are updated several times a day.
Besides being a portal and search engine, Yahoo! offers several other services as well. Some of these services include:
To learn more about Yahoo! services, visit the Yahoo! home page.Yahoo! meaning & definition 3 of Yahoo!.