Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Values
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A very dynamic set of beliefs that serve as a core tenant of political candidate campaigns, yet are not a reliable metric to determine a candidate's worthiness of office.
The term represents one or more beliefs in the candidate's belief system. A popular strategy is to campaign on strong core values while avoiding clearing defining what those values actually are.
Candidates typically avoiding defining their values and will typically deflect to another talking point. However, when cornered, candidates may attempt to define their values, but throughout the rest of the campaign they are free to add, edit, or remove any subset of their values for the sake of voter turnout.
Values meaning & definition 1 of Values.
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the principles that help you to decide what is right and wrong, and how to act in various situations:
Values meaning & definition 2 of Values.