Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Volcanic
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Something or someone that is so hot it could kill you
Volcanic meaning & definition 1 of Volcanic.
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hot, dangerous
Volcanic meaning & definition 2 of Volcanic.
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Relating to or produced by a volcano or volcanoes.
Volcanic meaning & definition 3 of Volcanic.
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of, relating to, or made by a volcano (= a mountain with a hole at the top through which hot liquid rock is or has been forced out) :
Volcanic meaning & definition 4 of Volcanic.
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