Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Keyed
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Furnished with keys; as, a keyed instrument; also, set to akey, as a tune. Keyed bugle. See Kent bugle.
Keyed meaning & definition 1 of Keyed.
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High on marijuana.
Keyed meaning & definition 2 of Keyed.
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when ones vehicle or other expensive possession becomes defaced by someone scraping off the paint with their own set of keys
Keyed meaning & definition 3 of Keyed.
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Getting completely fucked up through the use of both alcohol and marijuana.
Keyed meaning & definition 4 of Keyed.
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When a person has taken a key and run it across the door of a car, thus scratching the paint.
Keyed meaning & definition 5 of Keyed.
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fucked up off the bomb weed.
Keyed meaning & definition 6 of Keyed.
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High on Cocaine
Keyed meaning & definition 7 of Keyed.
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1: To be really high on marijuana.
2: When there's only [resin] and no marijuana left in the [bowl] after smoking.Keyed meaning & definition 8 of Keyed.
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adj. Intoxicated with alcoholic liquor to the point of impairment of both physical and mental faculties.
Keyed meaning & definition 9 of Keyed.
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(of a locking mechanism or switch) operated by a key.
Keyed meaning & definition 10 of Keyed.
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