Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Frith
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A narrow arm of the sea; an estuary; the opening of a riverinto the sea; as, the Frith of Forth.
Frith meaning & definition 1 of Frith.
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Frith is an Old English word that means [Peace] and [Freedom]; but means so much more. It is an [important] concept in the religion of [Asatru]. It might be described as a combination of loyalty, honor, hospitality, and support. It is the obilgation to one's community, friends, and family to consider their welfare in your actions, and not to set out to harm them.
Frith meaning & definition 2 of Frith.
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the act of inserting something large up the [anal passage] Example: A cricket bat handle or a miniture baseball bat.
Frith meaning & definition 3 of Frith.
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