Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Vindication
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The claiming a thing as one's own; the asserting of a right ortitle in, or to, a thing. Burrill.
Vindication meaning & definition 1 of Vindication.
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Seriously wanting; one who seeks what they cannot become.
Vindication meaning & definition 2 of Vindication.
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An African dance move often performed with a steady bongo beat in the background.
Vindication meaning & definition 3 of Vindication.
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The action of clearing someone of blame or suspicion.
Vindication meaning & definition 4 of Vindication.
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the fact of proving that what someone said or did was right or true, after other people thought it was wrong:
Vindication meaning & definition 5 of Vindication.
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