Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Fledge
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Feathered; furnished with feathers or wings; able to fly.Hfledge with wings. Milton.
Fledge meaning & definition 1 of Fledge.
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An Elbow drive concentrated directly into the back of an person
Fledge meaning & definition 2 of Fledge.
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Verb, Sexual act, to fledge
The act of ejaculating in the rectum of your sexual partner and slurping it out with a straw.Fledge meaning & definition 3 of Fledge.
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same as number one. the one that comes first
Fledge meaning & definition 4 of Fledge.
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smelly old granny's pussy
Fledge meaning & definition 5 of Fledge.
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(of a young bird) develop wing feathers that are large enough for flight.
Fledge meaning & definition 6 of Fledge.
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