Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Bowie knife
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A knife with a strong blade from ten to fifteen inches long,and double-edged near the point; -- used as a hunting knife, andformerly as a weapon in the southwestern part of the United States.It was named from its inventor, Colonel James Bowie. Also, byextension, any large sheath knife.
Bowie knife meaning & definition 1 of Bowie knife.
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