Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Doughty
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Able; strong; valiant; redoubtable; as, a doughty hero.Sir Thopas wex [grew] a doughty swain. Chaucer.Doughty families, hugging old musty quarrels to their hearts, buffeteach other from generation to generation. Motley.
Doughty meaning & definition 1 of Doughty.
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Used to describe high quality marijuana. Also reffered to as dro, chronic and other nicknames
Doughty meaning & definition 2 of Doughty.
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brave, strong, and determined
Doughty meaning & definition 3 of Doughty.
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An expired pseudonym for [Mike Doughty], sole Guardian, and perpetuator of the [Small Rock]. Was once front man of [Soul Coughing].
See also [Mike Doughty], [M Doughty]Doughty meaning & definition 4 of Doughty.
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A very slow spacey kind of person. Could be considered stupid or strange. Or not all there!
Doughty meaning & definition 5 of Doughty.
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One who fucks fat folded floppy titty freaks Named Stepany!!!. ALso Has acorns for muscles. He also thinks hes good and has no friends. And loves [double anal fisting]....and loves the [fuck stick] most of all
Doughty meaning & definition 6 of Doughty.
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determined, brave, and unwilling ever to stop trying to achieve something:
Doughty meaning & definition 7 of Doughty.
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Brave and persistent.
Doughty meaning & definition 8 of Doughty.