Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Postilion
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One who rides and guides the first pair of horses of a coach orpost chaise; also, one who rides one of the horses when one pair onlyis used. [Written also postillion.]
Postilion meaning & definition 1 of Postilion.
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to give sexual pleasure by inserting a finger into the anus.
Postilion meaning & definition 2 of Postilion.
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