Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Sulk
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to sulk, to sit in corner, and pout, pout,
Sulk meaning & definition 1 of Sulk.
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same as (johns). to crave or desire something.to jones.
Sulk meaning & definition 2 of Sulk.
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acronym used to describe an ugly person, stands for Screwed Up Looking Kid.
Sulk meaning & definition 3 of Sulk.
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Also known as ham. A sulk is an individual who is very attractive, and whos arse is extremely fuckable.
Sulk meaning & definition 4 of Sulk.
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Be silent, morose, and bad-tempered out of annoyance or disappointment.
Sulk meaning & definition 5 of Sulk.
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