Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Barrier
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A carpentry obstruction, stockade, or other obstacle made in apassage in order to stop an enemy.
Barrier meaning & definition 1 of Barrier.
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cock block; INTERRUPTER
Barrier meaning & definition 2 of Barrier.
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That person you always stand in back of that stops randomly or is really, really slow. Especially annoying if you're in a hurry or at school. Can be people or cars.
Barrier meaning & definition 3 of Barrier.
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Slang for a sexually unbroken hymen.
Barrier meaning & definition 4 of Barrier.
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Barrier in Figure Skating. The low wooden or plastic wall marking the edge of the ice surface that surrounds the rink.
Barrier meaning & definition 5 of Barrier.
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A fence or other obstacle that prevents movement or access.
Barrier meaning & definition 6 of Barrier.
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