Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Loaf
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Any thick lump, mass, or cake; especially, a large regularlyshaped or molded mass, as of bread, sugar, or cake. Bacon. Loafsugar, refined sugar that has been formed into a conical loaf in amold.
Loaf meaning & definition 1 of Loaf.
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when a fat cat sits laying on its
Loaf meaning & definition 2 of Loaf.
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Short for Loaf
Loaf meaning & definition 3 of Loaf.
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A turd.(Esp. an elongated turd with a tapered end)
Loaf meaning & definition 4 of Loaf.
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Someone who knowingly takes too long to do something.
Loaf meaning & definition 5 of Loaf.
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This is another word for chill, or relax. The most awesome fucking synonym for those words you will ever hear. It will make you wanna LOAF.
Loaf meaning & definition 6 of Loaf.
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Ghetto way of saying failing/failure or being
Loaf meaning & definition 7 of Loaf.
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A silly person who is often really happy all the time for no apparent reason. They are also weird and do weird stuff.
Loaf meaning & definition 8 of Loaf.
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Large Overly-Aggressive Female.
Women who tend to be on the hefty side who intimidate those around them. Usually when they are a tad intoxicated and trying to make sexual advances. Can also be used in the context of scary, large women seen in everyday life.Loaf meaning & definition 9 of Loaf.
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Verb: To Loaf-- Colloquial form of language expressing the observation of someone else’s or one’s own flatulence and or incontinence. The release of gaseous fecal odors.
Noun: Loaf-- Gaseous Fecal Odor
Adjective: Loafy-- Smelling like gaseous fecal odor
Position of entitlement: Dr. Loafenstein, The LoafmanLoaf meaning & definition 10 of Loaf.
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So this can either be your standard loaf of bread, whole wheat and healthy or white alike.
This can ALSO be to sit around and waste time and procrastinate on a couch. Y'know?
Loaf meaning & definition 11 of Loaf.