Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Conviction
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A judgment of condemnation entered by a court havingjurisdiction; the act or process of finding guilty, or the state ofbeing found guilty of any crime by a legal tribunal.Conviction may accrue two ways. Blackstone.
Conviction meaning & definition 1 of Conviction.
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Belief that one would die for.
Conviction meaning & definition 2 of Conviction.
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A new show starring Stephanie March as Alex Cabot. It will air on NBC in Spring of 2006. It's created by Dick Wolf. It will be similar to his Law
Conviction meaning & definition 3 of Conviction.
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