Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Generification
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The act or process of generalizing.Out of this the universal is elaborated by generification. Sir W.Hamilton.
Generification meaning & definition 1 of Generification.
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The process of exterimninating the middle class and poor residents of a city due to high inflated real estate prices that will bring along wealthy yuppies into neighborhoods that were once blue collar middle collar class.
Real estate developers advertise certain neighborhoods as trendy in hopoe to bring in yuppies and drive out long time residents.Generification meaning & definition 2 of Generification.
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