Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Drouth
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Same as Drought. Sandys.Another ill accident is drouth at the spindling of corn. Bacon.One whose drouth [thirst], Yet scarce allayed, still eyes the currentstream. Milton.In the dust and drouth of London life. Tennyson.
Drouth meaning & definition 1 of Drouth.
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[Scots] word meaning thirst
pronounced drooth with the emphasis on the 'r'Drouth meaning & definition 2 of Drouth.
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Pronounced 'drowth'
Most commonly experienced at an agency pitch or important client meeting. A severe case of dry mouth which causes you to stutter, clam up and/or waffle.
Drouth meaning & definition 3 of Drouth.
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