Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Dowel
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To fasten together by dowels; to furnish with dowels; as, acooper dowels pieces for the head of a cask.
Dowel meaning & definition 1 of Dowel.
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A plugged cigar. A cigar rolled so tight you can't pull the smoke.
Dowel meaning & definition 2 of Dowel.
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A good pal that is very vital to your life style.
Dowel meaning & definition 3 of Dowel.
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A projecting peg used for holding together components of a structure.
Dowel meaning & definition 4 of Dowel.
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A peg of wood, metal, or plastic without a distinct head, used for holding together components of a structure.
Dowel meaning & definition 5 of Dowel.
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