Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Bump off
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to kill, especially a planned hit.
Bump off meaning & definition 1 of Bump off.
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Bump off is rugby and rugby league terminology for one player hitting another player with there body resulting in the other player to fall to the ground
Bump off meaning & definition 2 of Bump off.
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Get out of my grill.
Bump off meaning & definition 3 of Bump off.
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When the unsub doesnt have anymoney to buy dope he can take a phone and bump it off for the dope .
Bump off meaning & definition 4 of Bump off.
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