Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Yipe
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- The sound made when one is startled, or surprised by the sudden pull or gravity.
- Common pronounciation for a difficult, but clever, German last name.
Yipe meaning & definition 1 of Yipe.
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A derogatory term for an ankle-biting ridiculously small dog that barks constantly.
Yipe meaning & definition 2 of Yipe.
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a cock, a dick, a penis, a male reproductive organ
Yipe meaning & definition 3 of Yipe.
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A word used to express utter unwillingness to do a task
Yipe meaning & definition 4 of Yipe.
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An expression of surprise, fear, pain, etc.
Yipe meaning & definition 5 of Yipe.
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