Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Unspeakable
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Something that is indescribable.
Unspeakable meaning & definition 1 of Unspeakable.
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A person so hot, theyre unspeakably hot.
Unspeakable meaning & definition 2 of Unspeakable.
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The act of falling asleep in a co-workers (of the opposite sex) vehicle on the way back from lunch, and waking up completely erect for all to see.
Unspeakable meaning & definition 3 of Unspeakable.
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too bad or shocking to be expressed in words:
Unspeakable meaning & definition 4 of Unspeakable.
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Not able to be expressed in words.
Unspeakable meaning & definition 5 of Unspeakable.
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