Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Tool shed
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The Kappa Sigma fraternity house at the University of Tulsa.
Tool shed meaning & definition 1 of Tool shed.
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A bar with a very poor male to female ratio.
Tool shed meaning & definition 2 of Tool shed.
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A slut (a tool being a male reprodtive organ, a shed being a place to put it.
Tool shed meaning & definition 3 of Tool shed.
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A place where [tools] like to frequent.
Tool shed meaning & definition 4 of Tool shed.
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Variation of the common term [tool] meaning loser. This takes it to another level of tooldom. These low lifes are sometimes just referred to as sheds
Tool shed meaning & definition 5 of Tool shed.
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when a group of more than one tool gather around in the same place and engage in toolish acts
Tool shed meaning & definition 6 of Tool shed.
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The tool shed, for overweight men, would be the area just above the penis (another slang term for this area is the F.U.P.A. - Frontal Upper Pubic Area) The extra fat surrounds the penis, protecting it as a tool shed protects its tools.
Tool shed meaning & definition 7 of Tool shed.
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