Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Weeper
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Moisture that appears through the cracks on a road surface after a [rainfall]. Primarily referenced in [NASCAR] and other forms of [motorsports].
Weeper meaning & definition 1 of Weeper.
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An opium addict. See [hop-head].
Weeper meaning & definition 2 of Weeper.
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A word that everyone else is okay to define because everyone is secretly a racist.
Weeper meaning & definition 3 of Weeper.
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A person who weeps.
Weeper meaning & definition 4 of Weeper.
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