Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Gemmer
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People 12 and under who spend money on Clash of clans!
Gemmer meaning & definition 1 of Gemmer.
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to describe someone in Clash of Clans as a bad player because they buy the in-game currency and advance to the top level, rather than learn over time.
Gemmer meaning & definition 2 of Gemmer.
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A person who plays an online game (ex. Clash of clans, clash royale, or any other who use a higher tier currency within the game) and spends real life money on the game to advance to higher levels instead of just playing and working for their in game levels or items.
Gemmer meaning & definition 3 of Gemmer.
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