Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Kibitz
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To meddle and give unwanted advice. kuh-Ib-itz
Kibitz meaning & definition 1 of Kibitz.
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To sit in on a conversation, meeting, card-game or online chat and offer unsolicited, informal comments. The original meaning from Yiddish (kibitzen, derived from German kiebitzen - to be an onlooker or spectator) had a negative connotation of being a busybody or giving intrusive, meddlesome, unwanted advice. However, in contemporary US usage, it has become friendlier.
Kibitz meaning & definition 2 of Kibitz.
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to give unwanted or intrusive advice to someone in a game or performance while watching(from German Via Yiddish)
Kibitz meaning & definition 3 of Kibitz.
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Kibitz: to sit out of a game and just watch.
Derivatives include kibitzing and kibitzed.
Kibitz meaning & definition 4 of Kibitz.
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A top secret organization that is devoted to stealing peoples passwords and talking about music.
Kibitz meaning & definition 5 of Kibitz.
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Look on and offer unwelcome advice, especially at a card game.
Kibitz meaning & definition 6 of Kibitz.