Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Monday
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The second day of the week; the day following Sunday.
Monday meaning & definition 1 of Monday.
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a word that can be used to describe a black person without insulting them with them knowing.
This word is relativley close to nigger.Monday meaning & definition 2 of Monday.
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The reason Sunday's suck.
Monday meaning & definition 3 of Monday.
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The biggest waste, of exactly one seventh of your life.
Monday meaning & definition 4 of Monday.
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The beginning of the schoolweek (and, for most people with decent occupations, the workweek). Its beginning puts almost everybody in a bad mood, but its end does little to enliven the spirit.
Monday meaning & definition 5 of Monday.
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someone or something you hate with an extreme prejudice.
Monday meaning & definition 6 of Monday.
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The worlds way of telling us, Here, take this you little bitch.
Monday meaning & definition 7 of Monday.
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The day everybody hates to have to put up with. Monday is the morning of the week, and it gives a general tired feeling and the return to work or school. It has worse weather than the other days of the week, too. Dreary and puts you in a bad mood.
Monday meaning & definition 8 of Monday.