Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Gainer
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A person who, usually due to the sexual stimulation he/she obtains from it, intentionally gains weight.
Gainer meaning & definition 1 of Gainer.
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A running reverse backflip that can be done off a springboard or a platform. Many people cant do them due to the mental block of going upside down, but they really arent that hard.
Gainer meaning & definition 2 of Gainer.
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A backflip while moving forward, usually done off of one foot while running
Gainer meaning & definition 3 of Gainer.
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Gainer is slang for the diving trick reverse. The category number is 300. For Example, a reverse flip (usually the term for gainer) is 302, and reverse double would be 304. A reverve is done when walking forward with a full approach, and not running. Many inexperienced divers run on the board, and could very easily slip. Gainer 2 and a half, 305, pike is the dive Greg Lougains hit his head on in the Olympics.
Gainer meaning & definition 4 of Gainer.
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a tricking move that is a one footed back flip.
Gainer meaning & definition 5 of Gainer.
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A hard dick that smells like laundry detergent
Gainer meaning & definition 6 of Gainer.
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One having sex with a nanny, or babysitter in austin
Gainer meaning & definition 7 of Gainer.
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one who makes horse noises when lifting weight; also another word for taking a dump.
Gainer meaning & definition 8 of Gainer.
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something or someone that is in a better position or has more value at the end of a process:
Gainer meaning & definition 9 of Gainer.