Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Unnecessary
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[unnecessary] [unnecessary] [unnecessary]
Unnecessary meaning & definition 1 of Unnecessary.
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Is a boner that comes in a bad time, like in your office, your classroom, hospital while getting a check up or while getting a massage.
Unnecessary meaning & definition 2 of Unnecessary.
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Huge papers that you have to write in a short amount of time.
Unnecessary meaning & definition 3 of Unnecessary.
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feeling extremely stoned.
Unnecessary meaning & definition 4 of Unnecessary.
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pointless stupid cock random unwanted useless annoying crazy dick dumb excessive extra funny impress penis prick ridiculous superfluous verbage verbcessitate verbcessitating verbcessitation work Solid
Unnecessary meaning & definition 5 of Unnecessary.
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Like perfume on a hog
Unnecessary meaning & definition 6 of Unnecessary.
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not needed or wanted, or more than is needed or wanted:
Unnecessary meaning & definition 7 of Unnecessary.
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