Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Bonce
-
your head
Bonce meaning & definition 1 of Bonce.
-
brainbox, brainy person.
Bonce meaning & definition 2 of Bonce.
-
to bonce somebody
this involves a sharp blow to the bonce using the fist. often accompanined with the word bonce or followed by i bonced u goodthe louder the scream the better the boncing
Bonce meaning & definition 3 of Bonce.
-
when something is in like seriously [cool] [hot] [sexy] [fit] [buff]
Bonce meaning & definition 4 of Bonce.
-
a bonce is to insult somebody about have a small sexual part.
Bonce meaning & definition 5 of Bonce.
-
cool, to enjoy, something you say to replace awesome when one is drunk and/or high
Bonce meaning & definition 6 of Bonce.
-
To leave with style. Modern equivalent of riding into the sunset.
Evolution of the word bounce.
Bonce meaning & definition 7 of Bonce.
-
A [bald] [sex offender] (Pedophile)
Derived from a mixture of the words bald and [nonce]Bonce meaning & definition 8 of Bonce.
-
A person
Bonce meaning & definition 9 of Bonce.
Similar Words