Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Unqualified
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Donald Trump.
Unqualified meaning & definition 1 of Unqualified.
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When youre so high, youre not able to do anything seriously or go in public without people noticing youre high.
Unqualified meaning & definition 2 of Unqualified.
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An unqualified person does not have the qualifications needed for a particular job.
Unqualified meaning & definition 3 of Unqualified.
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(of a person) not officially recognized as a practitioner of a particular profession or activity through having satisfied the relevant conditions or requirements.
Unqualified meaning & definition 4 of Unqualified.
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