Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Everest
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The ultimate goal that you set for yourself; one that has many obstacles in the way of achieving, however, once achieved the reward is great.
Everest meaning & definition 1 of Everest.
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A really tall person.
Everest meaning & definition 2 of Everest.
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A funny, cute guy that is really musically talented
Everest meaning & definition 3 of Everest.
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Unorganized Institution. An office or school that has no communication between staff, students, employers, etc.
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A group of schools or businesses getting shut down due to being dropped on their butt by its owner company, low customers, bad reviews. Dave Ramsey couldnt help.
Everest meaning & definition 4 of Everest.
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A really smart wanna-be man whore. Generally has a pretty large ego, but is still a nice person.
Everest meaning & definition 5 of Everest.
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A form of getting high off continuous laughter, as if on everest and short of breath
Everest meaning & definition 6 of Everest.
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Manage customer complaints professionally; well beyond help desk applications. Capture, communicate, classify and document everything. A software product by Lynk Software
Everest meaning & definition 7 of Everest.