Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Topman
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The menswear branch of [topshop] - a highly profitable British fashion chain store in the [Arcadia] group - Topman is the most popular menswear store in the UK.
Wants you to wear striped skinny Tees, skinny jeans, skinny ties and skinny braces. But only if youre skinny, and can actually fit into their clobber. They generally cater for the younger man and provide discounts to students.
The Oxford Street Flagship store in London is a recklessly huge affair, and carries exclusive designer lines that you cant afford.
Topman meaning & definition 1 of Topman.
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One who wears stereotypical Top Man clothing. Usually identified by shirts
Topman meaning & definition 2 of Topman.
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when a person is cool or when they have done something to please you
can be applied to girls
TopgirlTopman meaning & definition 3 of Topman.
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Topman meaning & definition 4 of Topman.
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